News | Stents Drug Eluting | January 25, 2018

Biotronik Symposium Highlights Differing Roles of Drug-Eluting Stents and Magnesium Scaffolds in Clinical Practice

Vascular intervention / BIOFLOW-V trial confirms leading clinical performance for Orsiro; new Magmaris data presents potentially lower risk of neoatherosclerosis formation

Biotronik Symposium Highlights Differing Roles of Drug-Eluting Stents and Magnesium Scaffolds in Clinical Practice

January 25, 2018 – Data presented at the Biotronik-sponsored symposium on the Orsiro drug-eluting stent (DES) demonstrate why Orsiro is gaining prominence in the crowded DES market. In addition, clinical and preclinical data presented about Magmaris reinforce the case that the magnesium-based resorbable technology does not share the same risk of acute and late scaffold thrombosis as the controversial poly-L-lactide (PLLA) alternative.

Jacques Koolen, cardiologist at Catharina Hospital, Eindhoven, Netherlands, and co-principle investigator and steering committee member of the BIOFLOW-V study, presented the latest addition to Orsiro’s body of clinical evidence. In this large international study, Orsiro reached unequivocal non-inferiority in the primary endpoint of target lesion failure (TLF) at 12 months versus Xience (6.2 percent vs 9.6 percent, p=0.04). Furthermore, a post-hoc superiority analysis demonstrated a 96.9 percent probability of Orsiro being superior to Xience in terms of TLF at 12 months.

William Wijns, professor of interventional cardiology at the Lambe Institute for Translational Medicine, Galway, Ireland, explored the question: why do we need scaffolds? “While recognizing the limitations of currently available resorbable scaffolds, we must also acknowledge that DESs still show progression of events in the late follow-up,” Wijns stated. “The goal of resorbable scaffolds is not only to decrease or eliminate those late events but also to restore the vessel anatomy and functionality, to restore a low thrombogenic milieu and potentially eliminate neoatherosclerosis.”

Finally, Michael Joner, professor of interventional cardiology at the German Heart Center, Munich, Germany, presented new Magmaris preclinical results. As Magmaris still reports zero percent definite and probable scaffold thrombosis in clinical trials, Joner presented new results on the formation of neoatherosclerosis with Magmaris compared to a stainless steel equivalent with identical design. The results demonstrate that Magmaris shows significantly lower levels of lipid-laden foamy macrophages – a sign of early neoatherosclerosis, compared to the stainless steel version.

“These results once more lead us to believe that the backbone material might be influencing the outcomes, and that vascular restoration occurs early in Magmaris allowing for compensatory vessel remodeling,” stated Joner.

For more information:

Related Content

Videos | Cath Lab | August 13, 2018
Jeffrey Schussler, M.D., FACC, FSCAI, FSCCT, FACP, interventional cardiologist at Baylor Scott White Heart and Vascul
Shockwave Launches Coronary Intravascular Lithotripsy in Europe
News | Cath Lab | May 30, 2018
Shockwave Medical recently announced the European commercial availability of Intravascular Lithotripsy (IVL) for...
FFR software on the GE Centricity CVIS. A trial from the 2018 EuroPCR meeting showed FFR improves long-term outcomes.
News | Cath Lab | May 29, 2018
May 29, 2018 — Ongoing controversy exists regarding the role of percutaneous coronary intervention (PCI) for stable c
SCAI Updates Consensus on Length of Stay for Percutaneous Coronary Intervention
News | Cath Lab | May 15, 2018
Revised guidelines incorporating new data on discharge criteria for patients undergoing elective percutaneous coronary...
No Benefit Found Using Sodium Bicarbonate, Acetylcysteine to Prevent Kidney Injury, the result of the PRESERVE Trial to prevent acute kidney injury (AKI), presented at SCAI 2018.  #SCAI, #SCAI2018,
Feature | Cath Lab | May 15, 2018
May 15, 2018 – The large-scale, international randomized PRESERVE clinical trial found high-risk patients for renal c
Angiogram of a STEMI patient.
News | Cath Lab | May 15, 2018
May 15, 2018 — A contemporary, real-world analysis shows lower mortality rates when culprit-only intervention is used
Recent Acquisitions Eroding Prices in Billion Dollar European Interventional Cardiology cath lab Market.
Feature | Cath Lab | May 07, 2018 | Simon Trinh and Jeffrey Wong
The European interventional cardiology market is currently valued at nearly $1.4 billion.
Videos | Cath Lab | May 07, 2018
Imran Ahmad, M.D., medical director of interventional cardiology, explains some of the new technologies his labs have
360 Photos | Cath Lab | April 20, 2018
A 360 degree view of the newest cath lab at Northwestern Medicine Central DuPage Hospital in Winfield, Ill., located
SCAI Announces Global Lecture Series for 2018 Scientific Sessions
News | Cath Lab | April 18, 2018
Many of the world’s leading interventional cardiologists and cardiovascular professionals will convene in San Diego,...
Overlay Init