News | Pharmaceuticals | May 13, 2022

Bristol Myers Squibb’s Mavacamten Poised to Stand unchallenged

Mavacamten estimated sales just shy of $1 billion if approved for common cardiomyopathy subtype, says GlobalData

Mavacamten estimated sales just shy of $1 billion if approved for common cardiomyopathy subtype, says GlobalData

Getty Images


May 13, 2022 — Bristol Myers Squibb’s mavacamten will stand rather unchallenged in the hypertrophic cardiomyopathy (HCM) market, achieving around $958 million in sales by 2025, according to GlobalData, a leading data and analytics company.

Sarah Bundra, Pharmaceutical Analyst at GlobalData, commented: “Mavacamten will be the first drug to specifically target obstructive HCM, which is a common form of cardiomyopathy. It has a unique mechanism of action (MoA)—being a myosin inhibitor—that more closely targets the pathophysiology of the disease.”

Existing cardiomyopathy therapies are generic and used for a wide range of cardiovascular diseases. Mavacamten can be used in conjunction with marketed therapies, such as beta blockers. As such, the drug will not displace any current therapy options, but will address a key cardiomyopathy demographic that has not previously been the target of clinical trial development.

Mavacamten’s performance in the VALOR-HCM study—whereby only 18% of participants still needed surgical intervention after 16 weeks—highlight its strength and potential in this market. This is even more impressive compared to placebo, of which 77% still needed surgery after the same time frame. Mavacamten has proved it can offer patients a chance to avoid invasive and costly procedures. Other reports from the VALOR-HCM study show that the majority of patients requested to continue the drug after the 16-week study period, suggesting a favorable safety profile.

Bundra adds: “Dr. Desai’s VALOR-HCM study results give obstructive HCM patients reasons to be excited.”

For more information: https://www.globaldata.com/

More ACC22 coverage can be found here

Related content:

Mavacamten Dramatically Cuts Need for Surgical Intervention for People with Obstructive Hypertrophic Cardiomyopathy

Cardiogenic Shock Market Outlook

ACC22: Transforming Cardiovascular Care

FDA Approves Bristol Myers' Camzyos (mavacamten) Oral Heart Disease Drug


Related Content

News | Pharmaceuticals

July 10, 2024 — Reviva Pharmaceuticals Holdings, Inc., a late-stage pharmaceutical company developing therapies that ...

Home July 10, 2024
Home
News | Pharmaceuticals

June 5, 2024 — Lexicon Pharmaceuticals, Inc. (Nasdaq: LXRX) today announced a new post-hoc analysis of clinical data ...

Home June 05, 2024
Home
News | Pharmaceuticals

May 24, 2024 — Lexicon Pharmaceuticals, Inc. announced a new post-hoc analysis of clinical data showing that INPEFA ...

Home May 24, 2024
Home
News | Pharmaceuticals

May 6, 2024 — Tenax Therapeutics, Inc., a Phase 3, development-stage pharmaceutical company focused on identifying ...

Home May 06, 2024
Home
News | Pharmaceuticals

February 16, 2024 — AMO Pharma Limited, a privately held clinical-stage specialty biopharmaceutical company focusing on ...

Home February 16, 2024
Home
News | Pharmaceuticals

January 25, 2024 — Agepha Pharma, a leading multinational pharmaceutical company with the first FDA-approved anti ...

Home January 25, 2024
Home
News | Pharmaceuticals

November 21, 2023 — BridgeBio Pharma, Inc., a commercial-stage biopharmaceutical company focused on genetic diseases and ...

Home November 21, 2023
Home
Feature | Pharmaceuticals | By Christine Book

In a new 3-part video series on hypertrophic cardiomyopathy with Christine E. Seidman, MD, FACC, FAHA, Managing Editor ...

Home October 25, 2023
Home
Videos | Pharmaceuticals

In this third and final segment in DAIC’s “One on One” series with Dr. Christine Seidman, learn what’s on the horizon at ...

Home September 26, 2023
Home
Subscribe Now