January 4, 2012 - A study reported in the current issue of Pediatric and Developmental Pathology compares cardiac tissue from 12 patients with histiocytoid cardiomyopathy (HC) and 12 age-matched controls. Researchers found differences in gene expression that could indicate a predisposition for HC.
HC typically occurs in the first two years of life. It affects females three times more often than males, leading to the theory that it is an X chromosome-linked disorder, with prenatal death occurring in males. Eighty percent of the cases occur in whites 15 percent in blacks and 3 percent in Latin Americans. It is very rare in those of Asian heritage.
A worldwide registry of HC was started in 1999, attempting to identify the gene responsible for the fatal disorder. These data have shown a family tendency for HC.
The gene analysis undertaken in the current study found decreased protein expression, or downregulation, in two sets of genes aligned sequentially along the genome. This offers several genes as candidates for the mutation, possibly predisposing individuals to HC.
The downregulation of a particular gene could result in reduced survival of cardiac myocytes, leading to cardiac failure during a baby’s development. These candidate genes will now offer a starting point for further research into inherited patterns of mutation. Utilizing the HC registry, researchers will seek to confirm the findings of this study and to collect and analyze blood from parents and siblings of HC patients in an effort to further expose the inheritance pattern.
Full text of the article, “Identification of Candidate Genes for Histiocytoid Cardiomyopathy (HC) Using Whole Genome Expression Analysis: Analyzing Material from the HC Registry,” Pediatric and Developmental Pathology, Vol. 14, No. 5, 2011, is available at http://www.pedpath.org/doi/full/10.2350/10-05-0826-OA.1
For more information: www.pedpath.org