News | Heart Failure | September 19, 2017

Heart Failure Market to Surpass $16 Billion by 2026

GlobalData report says growing uptake of Novartis’ Entresto will drive much of the anticipated growth

Heart Failure Market to Surpass $16 Billion by 2026

September 19, 2017 — The heart failure space across the seven key markets of the U.S., France, Germany, Italy, Spain, the U.K. and Japan is set to grow from $3.7 billion in 2016 to around $16.1 billion by 2026, according to research and consulting firm GlobalData. This represents an impressive compound annual growth rate of 15.7 percent.

The company’s latest report states that the strongest driver of this rise in market value will be the growing uptake of Novartis’ Entresto over the forecast period, despite initial modest sales. Other drivers will include the launch of several chronic heart failure therapies, including Amgen and Cytokinetics’ omecamtiv mecarbil, and an increase in the global prevalence of chronic heart failure and incidence of acute heart failure.

Elizabeth Hamson, Ph.D., healthcare analyst for GlobalData, explains: “Over the past two decades, chronic heart failure therapies have demonstrated success in slowing the progression of the disease and in reducing both mortality and morbidity in large-scale clinical trials. However, these successes have been limited to heart failure with reduced ejection fraction (HF-REF), showing only moderate benefits in heart failure with preserved ejection fraction (HF-PEF). Despite the lack of strong clinical evidence, guideline-recommended HF-REF therapies are widely used to treat HF-PEF.

“Based on this, drug developers have historically only targeted HF-REF in their drug strategies. With HF-PEF on the rise, however, this patient cohort represents a lucrative opportunity for pharmaceutical companies such as Novartis, which recently launched its first-in-class angiotensin receptor-neprilysin inhibitor Entresto in the U.S. for HF-REF, and is currently conducting late-stage trials of the drug in HF-PEF patients.”

GlobalData anticipates Entresto’s label expansions to HF-PEF to be approved in 2020, which will boost the drug’s uptake dramatically. Due to the lack of evidence-based therapies for HF-PEF, if Entresto proves to be efficacious in this patient, it will help Novartis further penetrate the heart failure market, undoubtedly benefitting the company immensely.

Hamson concluded: “Although it is thought that Entresto will fulfill a major unmet need over the forecast period, it is important to acknowledge that others will remain. For example, effective treatment of patients with multiple comorbidities, particularly those with renal impairment, will remain elusive. GlobalData does not expect this unmet need to be fulfilled during the forecast period, although the recent FDA [U.S. Food and Drug Administration] approval of several potassium-binding agents to treat hyperkalemia may relieve the burden of this unmet need to a slight extent.”

For more information: www.globaldata.com

Read the related article "Device Technologies to Reduce Heart Failure Readmissions."

Related Content

Cardiac Contractility Modulation Safe and Effective as Heart Failure Treatment

Image courtesy of Impulse Dynamics

News | Heart Failure | May 18, 2018
In a new study, cardiac contractility modulation (CCM) therapy was confirmed to significantly improve exercise...
V-Wave Closes $70M Financing to Support Pivotal Study of Heart Failure Therapy
News | Heart Failure | May 16, 2018
Israel-based V-Wave Ltd. recently closed a $70 million Series C financing for its proprietary, minimally invasive...
News | Heart Failure | May 14, 2018
Ancora Heart Inc. announced the expansion of the company’s U.S. feasibility study to evaluate the investigational...
Protein Clumping May Contribute to Heart Failure Development

A PET scan detects clumping proteins in rat hearts (top). The enlarged heart (right) is one with heart failure. Other PET scans showing blood flow in the rat hearts (bottom) show that the protein clumps aren't due to circulation problems. Image courtesy of Circulation Research, May 11, 2018.

News | Heart Failure | May 11, 2018
A team led by Johns Hopkins University Researchers has discovered that protein clumps appear to accumulate in the...
Minnesota Living With Heart Failure Questionnaire Qualified for FDA Medical Device Development Tools Program

The CORolla device from Israel-based CorAssist is one example of new devices being manufactured and tested to treat heart failure. The efficacy of this and other new devices under development can now be assessed with the Minnesota Living With Heart Failure Questionnaire. 

Technology | Heart Failure | May 07, 2018
The U.S. Food and Drug Administration (FDA) has qualified the Minnesota Living with Heart Failure Questionnaire from...
Nation's First Heart Failure and Arrhythmia Center Opening in Ohio

Image courtesy of The Ohio State University

News | Heart Failure | April 04, 2018
The Ohio State University Wexner Medical Center will establish the nation’s first center dedicated to treating those...
Abbott Initiates GUIDE-HF Trial for Improved Outcomes With CardioMEMS Monitor
News | Heart Failure | March 29, 2018
Abbott announced the company has initiated the landmark GUIDE-HF clinical trial using the CardioMEMS HF System. The...
Videos | Heart Failure | March 23, 2018
David Lanfear M.D., FACC, head of advanced heart failure and cardiac transplantation, Henry Ford Hospital, Detroit, d
Guideline Adherence, Not Patient Volume, May Be Better Hospital Heart Failure Metric
News | Heart Failure | February 01, 2018
February 1, 2018 –  In evaluating the quality of care given to those hospitalized with...
First-in-Man RenalGuard Studies Show Promise for Heart Failure Patients
News | Heart Failure | January 02, 2018
RenalGuard Solutions Inc. reported positive results from a first-in-man feasibility study focusing on a novel use of...
Overlay Init