News | June 14, 2010

High Levels of HDL Cholesterol May Also Help Prevent Cancer

June 14, 2010 - High levels of high-density lipoprotein (HDL) — known as good cholesterol — can not only make a person two to three times less likely to develop heart disease, but also may lower the risk of cancer. This is according to a study published in the June 22, 2010, issue of the Journal of the American College of Cardiology (JACC).

The study — the first comprehensive analysis of the relationship between HDL-C and cancer risk among statin trials — reveals a 36 percent lower rate of cancer for every 10 mg/dl higher level of HDL-C, which is independent of other potential risk factors including baseline LDL (bad) cholesterol, age, body mass index, diabetes, sex and smoking status.

“There is a strong and important relationship between the level of good cholesterol that people have in their blood and their risk of getting cancer. This supports another potentially important role for HDL in the body,” said Richard Karas, M.D., Ph.D., executive director of the Molecular Cardiology Research Institute at Tufts Medical Center in Boston and author of the study. “This finding is important because it builds on previous studies demonstrating that low levels of LDL or bad cholesterol and total cholesterol are associated with increased rates of cancer.”

The mechanisms by which HDL-C is protective against cancer have yet to be teased out, according to Dr. Karas, noting the current study does not imply a causal relationship. There are several plausible explanations for the beneficial effects of HDL-C that need further investigation, and include its:

• Antioxidant properties: Oxidants or oxidizing agents contribute to cancer risk by attacking DNA — the genes inside our cells — thereby converting healthy cells to cancerous cells. HDL may work by soaking up harmful oxidants and reducing cell damage.
• Role in immune surveillance: As HDL travels through the body, some experts suspect it may alter the immune system so that the body is better equipped to find and target developing cancers.
• Anti-inflammatory properties: A persistent proinflammatory state can sustain cancer cell growth and survival and has also been found to contribute to other chronic diseases; HDL may serve as a mediating factor, reducing inflammation.

Karas says patients should talk with their doctor about personal risk factors for both heart disease and cancer, adding that this study reinforces the importance of getting a full cholesterol screening panel that includes total cholesterol, LDL-C, HDL-C and triglycerides.

“Patients need to be informed and understand what each cholesterol number means for their overall health and risk of disease,” he said.

The best way to boost HDL levels is by adopting a healthy lifestyle — exercising regularly, eating a healthy diet, consuming alcohol only in moderation and not smoking cigarettes. For individuals who are considered at high risk for heart disease, there are medications available to help increase levels of HDL-C.

Determining whether HDL-C itself or its association with other health-promoting behaviors is playing a potential role in reducing one’s risk of cancer is challenging, as discussed in the accompanying JACC editorial.

“This study suggests that HDL might be an important marker for all lifestyle risk factors we know contribute to both heart disease and cancers — smoking, obesity and inflammation, for example,” said Jennifer Robinson, M.D., MPH, professor of epidemiology and medicine at the University of Iowa College of Public Health, and author of the editorial. “Since low HDL appears to be a marker for chronic disease risk, this is just another reason why we need to emphasize improved lifestyle among these patients.”

In a secondary analysis of other potential risk factors, authors confirmed their earlier report that LDL-C levels are inversely associated with the development of cancer. Data also showed a significant and direct association between both age and body mass index and the rate of incident cancer, such that every five-year increment in age was associated with a 33 percent relatively higher cancer rate and every 1-kg/m2 increment in BMI was associated with a 21 percent relatively higher cancer rate.

A total of 24 randomized controlled trials of lipid-altering interventions were identified and baseline HDL-C levels and incident cancers were analyzed across treatment and control arms. Taken together, these large-scale trials enrolled 145,743 patients; the median duration of follow up was five years, and there were 8,185 incidents of cancer reported.

For more information: www.acc.org

Related Content

A key slide from Elnabawi's presentation, showing cardiac CT plaque evaluations, showing the impact of psoriasis medication on coronary plaques at baseline and one year of treatment. It shows a reversal of vulnerable plaque development. #SCAI, #SCAI2018

A key slide from Elnabawi's presentation, showing cardiac CT plaque evaluations, showing the impact of psoriasis medication on coronary plaques at baseline and one year of treatment. It shows a reversal of vulnerable plaque development.  

Feature | Cardiovascular Clinical Studies | May 14, 2018
May 14, 2018 – New clinical evidance shows common therapy options for psoriasis (PSO), a chronic inflammatory skin di
Intravenous Drug Use is Causing Rise in Heart Valve Infections, Healthcare Costs. #SCAI, #SCAI2018
News | Cardiovascular Clinical Studies | May 14, 2018
May 14, 2018 — The opioid drug epidemic is impacting cardiology, with a new study finding the number of patients hosp
Patient Enrollment Completed in U.S. IDE Study of THERMOCOOL SMARTTOUCH SF Catheter
News | Cardiovascular Clinical Studies | March 15, 2018
March 15, 2018 –  Johnson & Johnson Medical Devices Companies announced today that Biosense Webster, Inc., who wo
Lexington Begins HeartSentry Clinical Trial
News | Cardiovascular Clinical Studies | February 20, 2018
February 20, 2018 – Lexington Biosciences, Inc., a development-stage medical device company, announced the commenceme
Endologix Completes Patient Enrollment in the ELEVATE IDE Clinical Study
News | Cardiovascular Clinical Studies | February 06, 2018
February 6, 2018 – Endologix, a developer and marketer of treatments for aortic disorders, announced the completion o
12-Month Results from Veryan Medical's MIMICS-2 IDE Study Presented at LINC
News | Cardiovascular Clinical Studies | February 01, 2018
February 1, 2018 – Thomas Zeller (Bad Krozingen, Germany) presented the 12-month results from Veryan Medical’s MIMICS
LimFlow Completes U.S. Feasibility Study Enrollment, Receives FDA Device Status
News | Cardiovascular Clinical Studies | February 01, 2018
February 1, 2018 –  LimFlow SA, developer of minimally-inv
ESC 2017 late breaking trial hot line study presentations.
News | Cardiovascular Clinical Studies | September 12, 2017
September 12, 2017 – The European Society of Cardiology (ESC) Congress 2017 includes several Hot Line Late-breaking C
U.K., NHS studies, weekend effect, hospital admission, atrial fibrillation, heart failure
News | Cardiovascular Clinical Studies | June 28, 2016
New research shows patients admitted to National Health Service (NHS) hospitals in the United Kingdom for atrial...
stroke risk
News | Cardiovascular Clinical Studies | August 28, 2015
Most people assume strokes only happen to octogenarians, but recent evidence suggests that survivors of childhood can
Overlay Init