News | January 07, 2015

Recent Cardiovascular Clinical Trials Framing Debate on Personalized Treatment, says GlobalData Analyst

Study revealed treatment with dual antiplatelet therapy decreased risk of stent thrombosis and major cardiovascular and cerebrovascular events

January 7, 2015 — Discussions regarding late-breaking cardiovascular clinical trials among leading medical scientists are placing considerable emphasis on individualized patient care, particularly in the area of dual antiplatelet therapy, according to an analyst with research and consulting firm GlobalData.

At the 2014 American Heart Association (AHA) meeting in Chicago, the results of the Dual Antiplatelet Therapy (DAPT) Study played a central role in presentations and debates regarding the use of antiplatelet blood-thinning agents.

Eric J. Dimise, Ph.D., GlobalData’s analyst covering Cardiovascular & Metabolic Disorders, states that the DAPT Study attempted to address an outstanding question concerning how long physicians should apply dual antiplatelet therapy following implantation of a drug-eluting stent (DES), with leading investigators concluding that the solution may depend upon individual patient needs.

Dimise says: “The study revealed that treatment with dual antiplatelet therapy (aspirin and clopidogrel or prasugrel) decreased the risk of stent thrombosis and major cardiovascular and cerebrovascular events, compared to treatment with aspirin alone during the 12 to 30-month period following implantation of a DES. However, this was achieved at the price of an increased frequency of bleeding.

“As a consequence, the debate now focuses on how physicians should strike a balance between reducing cardiovascular events while simultaneously minimizing bleeding risk.”

According to the analyst, it has been proposed that one should err on the side of short-term therapy for patients at high risk of bleeding, while therapy beyond 12 months should be considered for those at high risk of a recurrent ischemic event.

However, cases have been presented in favor of both short and long-term therapies, with the former leaning on the resultant diminution of bleeding events observed in the placebo group of the DAPT Study, and the latter arguing for the clear cardiovascular event-reduction benefit.

Dimise comments: “While some disagreements remain, there is a general consensus that individualization of therapy is likely to become the new norm, and that further studies should be conducted to help clarify which patient subpopulations would reap the most benefit from long and short-term therapy.”

For more information: www.globaldata.com

 

 

 

Related Content

A key slide from Elnabawi's presentation, showing cardiac CT plaque evaluations, showing the impact of psoriasis medication on coronary plaques at baseline and one year of treatment. It shows a reversal of vulnerable plaque development. #SCAI, #SCAI2018

A key slide from Elnabawi's presentation, showing cardiac CT plaque evaluations, showing the impact of psoriasis medication on coronary plaques at baseline and one year of treatment. It shows a reversal of vulnerable plaque development.  

Feature | Cardiovascular Clinical Studies | May 14, 2018
May 14, 2018 – New clinical evidance shows common therapy options for psoriasis (PSO), a chronic inflammatory skin di
Intravenous Drug Use is Causing Rise in Heart Valve Infections, Healthcare Costs. #SCAI, #SCAI2018
News | Cardiovascular Clinical Studies | May 14, 2018
May 14, 2018 — The opioid drug epidemic is impacting cardiology, with a new study finding the number of patients hosp
Patient Enrollment Completed in U.S. IDE Study of THERMOCOOL SMARTTOUCH SF Catheter
News | Cardiovascular Clinical Studies | March 15, 2018
March 15, 2018 –  Johnson & Johnson Medical Devices Companies announced today that Biosense Webster, Inc., who wo
Lexington Begins HeartSentry Clinical Trial
News | Cardiovascular Clinical Studies | February 20, 2018
February 20, 2018 – Lexington Biosciences, Inc., a development-stage medical device company, announced the commenceme
Endologix Completes Patient Enrollment in the ELEVATE IDE Clinical Study
News | Cardiovascular Clinical Studies | February 06, 2018
February 6, 2018 – Endologix, a developer and marketer of treatments for aortic disorders, announced the completion o
12-Month Results from Veryan Medical's MIMICS-2 IDE Study Presented at LINC
News | Cardiovascular Clinical Studies | February 01, 2018
February 1, 2018 – Thomas Zeller (Bad Krozingen, Germany) presented the 12-month results from Veryan Medical’s MIMICS
LimFlow Completes U.S. Feasibility Study Enrollment, Receives FDA Device Status
News | Cardiovascular Clinical Studies | February 01, 2018
February 1, 2018 –  LimFlow SA, developer of minimally-inv
ESC 2017 late breaking trial hot line study presentations.
News | Cardiovascular Clinical Studies | September 12, 2017
September 12, 2017 – The European Society of Cardiology (ESC) Congress 2017 includes several Hot Line Late-breaking C
U.K., NHS studies, weekend effect, hospital admission, atrial fibrillation, heart failure
News | Cardiovascular Clinical Studies | June 28, 2016
New research shows patients admitted to National Health Service (NHS) hospitals in the United Kingdom for atrial...
stroke risk
News | Cardiovascular Clinical Studies | August 28, 2015
Most people assume strokes only happen to octogenarians, but recent evidence suggests that survivors of childhood can
Overlay Init