News | Stem Cell Therapies | August 22, 2019

Renovacor Closes $11 Million Series A Financing for New Cardiovascular Gene Therapy

Funding supports preclinical development through IND submission for BAG3 gene therapy, the first gene replacement product for genetic forms of dilated cardiomyopathy

Renovacor Closes $11 Million Series A Financing for New Cardiovascular Gene Therapy

August 22, 2019 — Renovacor Inc, a preclinical-stage biopharmaceutical company, announced the successful completion of an $11 million Series A financing for its recombinant adeno-associated virus (AAV)-based gene therapy for dilated cardiomyopathy (DCM). The gene therapy is indicated for patients with DCM due to mutations in the BAG3 gene.

The foundational understanding of BAG3 mutations and the company’s gene therapy product are based on 10 years of research performed by Arthur Feldman, M.D., Ph.D., the Laura H. Carnell Professor of Medicine (Cardiology) at the Lewis Katz School of Medicine Temple University. Proceeds from the Series A financing will be used to advance the company’s first-of-its-kind gene replacement therapy through filing of an investigational new drug (IND) application in preparation to initiate human clinical trials in DCM patients who have mutations in their BAG3 gene.

Dilated cardiomyopathy is a condition affecting more than 3 million patients in the U.S. and growing steadily. Many patients develop DCM due to ischemic heart disease. Recently subpopulations have been identified that develop DCM due to mutations in specific genes that have been shown to result in the development of DCM. One of these specific genes is the Bcl2-associated athanogene 3 (BAG3) gene. The prevalence of disease causing BAG3 haploinsufficiency is estimated at approximately 35,000 individuals in the United States, representing an orphan disease by U.S. Food and Drug Administration (FDA) guidelines. It is estimated a similar number of DCM patients with BAG3 mutations exist in Europe. These patients are typically younger and progress to end-stage heart failure sooner than patients with ischemic heart disease. 

Currently DCM patients with a BAG3 mutation are treated with standard of care for heart failure. Despite improvements in pharmacotherapy and care, the five-year survival of a patient with DCM is only 50 percent. Development of a BAG3 gene replacement therapy for patients with DCM that carry BAG3 mutations could potentially prevent progression of disease in this otherwise healthy population of young adults.

The financing round was co-led by Novartis Venture Fund, Broadview Ventures and BioAdvance, and joined by New Leaf Venture Partners and Innogest Capital. In conjunction with the financing, Renovacor announced its leadership team and board of directors including Feldman, M.D., Ph.D., FACC, Renovacor’s founder; Magdalene Cook, M.D., Renovacor’s president/CEO; Thomas Needham, MBA, director, Broadview Ventures; Campbell Murray, M.D., managing director, Novartis Venture Fund; and Edward J. Benz, M.D., president and CEO emeritus of the Dana-Farber Cancer Institute, and currently the Richard and Susan Smith Distinguished Professor of Medicine, professor of pediatrics, and professor of pathology at Harvard Medical School.

For more information: www.renovacorinc.com

Related Content

News | Heart Failure

May 26, 2022 — Axon Therapies, a private company focused on addressing a root cause of heart failure, today announced ...

Home May 26, 2022
Home
News | Heart Failure

May 25, 2022 — Immune response and the lymphatic system are central to cardiac repair after a heart attack, according to ...

Home May 25, 2022
Home
News | Heart Failure

May 23, 2022 — Insights from a National Inpatient Sample Database examining race and the rates of cardiac ...

Home May 23, 2022
Home
News | Heart Failure

May 20, 2022 — Results from early clinical evaluation of the Alleviant System to treat heart failure patients with ...

Home May 20, 2022
Home
News | Heart Failure

May 19, 2022 — Cardionomic, Inc., a Minneapolis medical device company, is pleased to announce initial enrollment in ...

Home May 19, 2022
Home
News | Heart Failure

May 16, 2022 — The Agency for Science, Technology and Research’s (A*STAR) Genome Institute of Singapore (GIS) and ...

Home May 16, 2022
Home
News | Heart Failure

May 16, 2022 — Right heart failure (RHF) continues to be a major source of morbidity and mortality following left ...

Home May 16, 2022
Home
News | Heart Failure

May 5, 2022 – Cardiovascular disease is a group of conditions that can arise from a lack of physical activity, poor diet ...

Home May 05, 2022
Home
Feature | Heart Failure | By Jean-Luc Boulnois, Ph.D.

The current standard of care for heart failure (HF) is guideline-directed medical therapy combined with device-based ...

Home May 04, 2022
Home
News | Heart Failure
April 27, 2022 – The contractile and elastic properties of the heart are finely tuned. This is a prerequisite for the ...
Home April 27, 2022
Home
Subscribe Now