News | April 09, 2009

Stem Cell Treatment for Myocardial Disease Trial Largest of its Kind in U.S.

April 9, 2009 - A successful randomized, double-blinded, placebo-controlled phase 2 clinical trial using an intramyocardial injection of a patient’s own CD34 stem cells as treatment for refractory angina has been completed, and included 22 centers across the U.S.

The phase 2 study, designed to test the ability of a patient’s own stem cells (CD34 cells) to improve blood flow to the heart, could show the ability to improve heart function and reduce the possibility of events such as hospitalizations and heart failure in patients with refractory angina. A total of 167 patients were randomized and completed the injection procedure, and 162 patients completed the six-month evaluation.

“The results from this study provide the first significant evidence that a patient’s own stem cells can actually be used as a treatment for their heart disease,” said Douglas Losordo, M.D., lead author from Northwestern University, Chicago. “This study provides some hope for those patients with currently untreatable angina to be more active with less pain.”

Dr. Losordo presented the study “Randomized, Double-blind Placebo Controlled Phase 2 Study of Intramyocardial Injection of Autologous CD34+ Cells for Treatment of Refractory Angina during the recent ACC conference in Orlando, FL.

Phase 2 of the study provides information about appropriate endpoints regarding suitability and sample size of this therapy for a phase 3 efficacy study, the final study that will ultimately determine if the treatment works.

For more information: acc.org

Related Content

ESC 2017 late breaking trial hot line study presentations.
News | Clinical Study| September 12, 2017
September 12, 2017 – The European Society of Cardiology (ESC) Congress 2017 includes several Hot Line Late-breaking C
U.K., NHS studies, weekend effect, hospital admission, atrial fibrillation, heart failure
News | Clinical Study| June 28, 2016
New research shows patients admitted to National Health Service (NHS) hospitals in the United Kingdom for atrial...
stroke risk
News | Clinical Study| August 28, 2015
Most people assume strokes only happen to octogenarians, but recent evidence suggests that survivors of childhood can
Overlay Init