January 4, 2022 —  The U.S. Food and Drug Administration (FDA) has cleared Novartis' inclisiran (Leqvio), the first  small interfering RNA (siRNA) therapy to lower low-density lipoprotein cholesterol (LDL-C) with two doses a year, after an initial dose and one at three months. The drug provides effective and sustained LDL-C reduction of up to 52% vs. placebo for certain people with atherosclerotic cardiovascular disease (ASCVD) on maximally tolerated statin therapy.[1,2]
