News | April 28, 2010

FDG PET/CT Identifies Aortic Dissection

April 28, 2010 - Molecular imaging can help physicians identify aortic dissection and help guide treatment, according to research published in the May issue of The Journal of Nuclear Medicine.

Dissection occurs when a tear in the wall of the aorta causes blood to flow between the layers of the wall of the aorta and force the layers apart. Aortic dissection is the tenth leading cause of death in Western societies. It is the second most frequent cause of acute chest pain, but it is difficult to identify. However, positron emission tomography (PET) with the imaging agent fluorodeoxyglucose (FDG) and computed tomography (CT) may help determine the age of an aortic dissection, the degree of risk and the need for surgery.

"Many conventional forms of imaging are not able to clearly differentiate between acute and chronic dissection," said Hans-Henning Eckstein, M.D., Ph.D., professor at the Technical University of Munich in Germany and the corresponding author of "Imaging of Acute and Chronic Aortic Dissection by 18F-FDG PET/CT."
He added, "It is critical to patients' survival that doctors are able to verify acute or exclude chronic aortic dissection so they can decide the best course of treatment. [These might be] rushing the patient to surgery in some cases or using beta blockers to lower the blood pressure."

In the Munich study, researchers examined patients who had symptoms of aortic dissection and patients with chronic asymptomatic dissection using FDG PET/CT to acquire images of the affected area, just above the heart. These images were studied to determine the difference between the two forms of aortic dissection. The researchers reported that acute dissection of the aortic wall led to elevated metabolic activity in fresh lacerated segments of the aortic wall, while stable chronic aortic dissection showed no increased metabolic activity.

Researchers speculate that increased metabolic activity in cases of acute aortic dissection is due to repair mechanisms of the aortic wall injury, causing cell activation and accumulation. The low metabolic activity in chronic aortic dissection is due to scar tissue. The searchers concluded further studies are needed to prove these hypotheses.

Reference: Authors of, "Imaging of Acute and Chronic Aortic Dissection by 18F-FDG PET/CT," include: Christian Reeps, Jaroslav Pelisek, Manuela Gurdan, Alexander Zimmermann, Stefan Ockert, and Hans-Henning Eckstein, of the Clinic for Vascular Surgery, Klinikum-rechts-der-Isar, Technische Universität München, Munich, Germany; Ralph A. Bundschuh and Markus Essler, Clinic for Nuclear Medicine, Klinikum-rechts-der-Isar, Technische Universität München, Munich, Germany; and Martin Dobritz, Institute for Radiology, Klinikum-rechts-der-Isar, Technische Universität München, Munich, Germany.

For more information: www.snm.org

Related Content

ASNC and SNMMI Release Joint Document on Diagnosis, Treatment of Cardiac Sarcoidosis
News | Cardiac Imaging| August 18, 2017
August 18, 2017 — The American Society of...
New PET-CT Scan Improves Detection in Rare Cardiac Condition
News | PET-CT| July 25, 2017
Using a new imaging technique that can diagnose cardiac sarcoidosis much more accurately than traditional tests,...
Sponsored Content | Videos | Nuclear Imaging| April 28, 2017
David Wolinsky, M.D., director of nuclear cardiology at Cleveland Clinic Florida and past-president of the American S
stress, brain activity, cardiovascular risk, PET-CT, MGH, ISSMS, The Lancet study
News | Cardiac Diagnostics| January 18, 2017
A study led by Massachusetts General Hospital (MGH) and Icahn School of Medicine at Mount Sinai (ISSMS) investigators...
PET/CT, calcium blockages, heart attack risk, Intermountain study, American Heart Association, AHA Scientific Sessions 2016
News | PET-CT| November 15, 2016
Many people who experience chest pain but don’t have a heart attack breathe a big sigh of relief when a stress test...
PET/CT, atherosclerotic plaque detection, Stanford University

Application of dual-modality optical and PET/CT activity-based probe in experimental carotid inflammation model. Coronal noninvasive PET/CT scans of (A) healthy and (B) diseased mice with and without ligated carotid arteries respectively. Inset images show optical ex vivo florescence imagining of (A) healthy and (B) diseased carotid arteries.  PET/CT and optical images courtesy of Xiaowei Ma, Toshinobu Saito and Nimali Withana.

News | PET-CT| November 01, 2016
Researchers at Stanford University have demonstrated for the first time the use of a dual optical and positron emission...
GE Healthcare, Discovery MI PET/CT system, FDA clearance, RSNA 2016
Technology | PET-CT| October 05, 2016
GE Healthcare recently announced U.S. Food and Drug Administration (FDA) 510(k) clearance of its Discovery MI digital...
Philips, SNMMI 2016, Vereos digital PET/CT, time-of-flight, IntelliSpace 8.0, nuclear imaging
News | Nuclear Imaging| June 14, 2016
Philips announced it would be showcasing a variety of nuclear imaging solutions at the Society of Nuclear Medicine and...
cardiac PET, myocardial perfusion, PET-CT, cardiac perfusion

A PET-CT cardiac perfusion exam from a Siemens Biograph scanner. The black and white areas of the image show the CT imaging of the anatomy. The colored portion shows the PET overlay on the myocardium and is color-coded to show tracer uptake values. This can show areas of the heart muscle where there are perfusion defects cause by infarcts or coronary artery blockages due to a heart attack and help determine the severity of the ischemia.

Feature | PET Imaging| June 03, 2016 | Dave Fornell
Positron emission tomography (PET) is a nuclear imaging technology (also referred to as molecular imaging) that enabl
PET/CT scan, brain stress center, heart disease predictor, ACC.16
News | PET-CT| April 05, 2016
New research shows individuals with a greater degree of activity in the stress center of the brain also have more...
Overlay Init