News | Intra-Vascular Ultrasound (IVUS) | March 13, 2018

Infraredx Highlights Value of IVUS + NIRS for Detecting Lipid Core Plaque at ACC.18

Presentation bolsters company’s upcoming studies in IVUS + NIRS imaging including its highly-anticipated PROSPECT II and Lipid-Rich Plaque Study findings  

Infraredx Highlights Value of IVUS + NIRS for Detecting Lipid Core Plaque at ACC.18

March 13, 2018 –  Infraredx, a company that works in intravascular imaging for mapping coronary artery disease, today presented a poster at the American College of Cardiology (ACC) 67th Annual Scientific Session supporting the value of combination intravascular ultrasound (IVUS) and near-infrared spectroscopy (NIRS) imaging technology to identify lipid core plaque (LCP), an underlying cause of serious cardiac events. In the poster presentation, IVUS +NIRS demonstrated efficiencies in locating LCP within arteries, indicating the technology may be a better predictor of major adverse cardiac events (MACE) than the current methodology standard set forth by the PROSPECT study.

“This analysis validates the use of dual-modality IVUS + NIRS catheters to clearly pinpoint LCP with increased efficiency compared to IVUS alone,” said Jason Bottiglieri, president and CEO of Infraredx. “Unlike other imaging technologies, NIRS can readily distinguish areas of stable plaque from potentially dangerous LCP, which may enable cardiologists to more accurately predict and ultimately prevent serious heart attacks.”

At ACC, March 10-12, 2018, Infraredx presented Poster #241: A Correlative Study of NIRS Lipid Core Burden Index Versus Histological Plaque Disease Arc in Human Coronary Autopsy Specimens.

Study Methodology and Results

  • The PROSPECT Study found in a sub-study that the plaque disease arc via transverse IVUS was an additional independent predictor of non-culprit lesion of MACE. However, the area under the curve (AUC) parameter that was observed in the study was low (0.64) and the methodology only included use of gray-scale IVUS. 
  • Infraredx utilized a similar disease arc concept in an IVUS + NIRS autopsy study to reveal the benefits and limitations of the disease arc concept. Since underlying pathological truths can be known in an autopsy study, the degree to which disease arc finds lipid core plaques could be studied, as well as novel methods incorporating the unique IVUS + NIRS chemogram map of vessel lipid core could also be explored.
  • The study concluded that quickly locating areas of LCP with NIRS, and then assessing the disease arc on IVUS cross-sections of interest may be more targeted than use of the IVUS disease arc alone. It also may be more clinically efficient due to the automated and immediate generation of the NIRS chemogram.

“PROSPECT demonstrated that vulnerable plaques can be detected with IVUS technology, but with only modest predictive ability,” said Gregg Stone, M.D., Columbia University Medical Center and New York-Presbyterian Hospital. “As demonstrated in this study, NIRS offers the potential to further discriminate plaques, which are likely to be particularly high-risk such as those with high lipid content, a hypothesis that is being tested in ongoing PROSPECT II and LRP studies.”

For more information: www.infraredx.com


Related Content

News | ACC

February 29, 2024 — The American College of Cardiology (ACC) will soon be holding its ACC 73rd Annual Scientific Session ...

Home February 29, 2024
Home
News | ACC

February 14, 2024 — The American College of Cardiology’s newest registry offers data-driven insights on cardiac ...

Home February 14, 2024
Home
News | ACC

February 7, 2024 — The Consumer Technology Association (CTA) and the American College of Cardiology (ACC) are announcing ...

Home February 07, 2024
Home
News | ACC

February 2, 2024 — The American College of Cardiology’s Cardiac Oncology Conference, “Advancing the Cardiovascular Care ...

Home February 02, 2024
Home
News | ACC

January 25, 2024 — The American College of Cardiology’s Cardiovascular Summit (CV Summit) will take place on February 1 ...

Home January 25, 2024
Home
News | ACC

December 1, 2023 — For the third consecutive year, the Cardiac Catheterization Laboratory at The Mount Sinai Hospital ...

Home December 01, 2023
Home
News | ACC

September 12, 2023 — The American College of Cardiology, through a strategic collaboration with Amgen and Esperion, is ...

Home September 12, 2023
Home
News | ACC

August 9, 2023 — A joint statement by two medical associations has been issued on a new guideline for the treatment of ...

Home August 09, 2023
Home
News | ACC

July 20, 2023 — The ACC Board of Trustees (BOT) has approved the College's newest officers and trustees who will assume ...

Home July 20, 2023
Home
News | ACC

June 1, 2023 — The American College of Cardiology will host the annual Care of the Athletic Heart course on June 8-10 ...

Home June 01, 2023
Home
Subscribe Now