September 15, 2014 — A new gene-directed drug being tested through a research study called GENETIC-AF may improve care, quality of life and survival in patients with heart failure and atrial fibrillation (AF). A previous study showed the drug being evaluated, called bucindolol hydrochloride, reduced symptomatic AF when compared with placebo in patients with a specific gene variation, or genotype. In the current study, bucindolol, a betablocker, is being compared with another betablocker called metoprolol succinate, a heart failure drug approved by the U.S. Food and Drug Administration (FDA).