February 28, 2022 – The normal functioning of human body requires a steady flow of energy. This energy in the form of adenosine triphosphate (ATP) is produced by breaking down carbon sources like glucose, lipids, or amino acids. The tricarboxylic acid (TCA) cycle, one of the most important ATP-producing processes in the mitochondria, is a major hub of metabolites and is known for ensuring a fine balance between its cyclic intermediates, referred to as the 'metabolic flux.'