February 20, 2023 — A novel Stroke Preclinical Assessment Network (SPAN) identified potential neuroprotective effects from intravenous uric acid (UA) given with thrombolysis following acute ischemic stroke. Six independent laboratories performed a standard transient middle cerebral occlusion in equal numbers of males and females of young mice, young rats, aging mice, mice with diet-induced obesity, and rats with spontaneous hypertension.