Videos | Structural Heart | September 28, 2021

VIDEO: Roles of the Melody and Harmony Transcatheter Pulmonary Valves in Congenital Heart Disease

Tom Jones, M.D., director, cardiac cath labs, Seattle Children’s Hospital, and principle investigator of the Medtronic Harmony transcatheter pulmonary valve trial, explains the differences between the Melody and Harmony valves. He also explains the history of congenital heart transcatheter valve development over the past 20 years and how adult structural heart devices also developed side-by-side with these devices. 

Patients with tetralogy of fallot often received the ventricular outflow tract (RVOT) in an initial surgery and a second surgery in needed later for a pulmonary valve. As valves wear out, additional open heart surgeries are needed. The Harmony and Melody help reduce the number of open heart surgeries in these patients. Jones said the Harmony valve may help reduce or eliminate the need for open heart surgeries.

The Melody was the first transcatheter valve to gain approval for use in the United States. It was designed to treat patients who already had a surgically placed RVOT. The Harmony valve was then developed to address patients who also needed the RVOT. Between the two valves, Jones said the majority of congenital heart issues can now be treat.

Jones said about 40,000-50,000 babies are born each year in the United States with congenital heart defects that the Harmony and Melody valves might be used to help. He said the Melody valve was able to help about 25% of these patients, and the Harmony valve now can help the rest of these patients with a transcatheter solution. 

Related Congenital Heart Content:

VIDEO: Harmony Transcatheter Pulmonary Valve Has Good Outcomes at 1 Year — Interview with Tom Jones, M.D.

FDA Clears First Device to Treat Right Ventricular Outflow Tract Congenital Heart Disease 

FDA Expands Indication for Melody Transcatheter Valve for Failed Surgical Valves

VIDEO: The Heart Team Approach in Congenital Structural Heart Interventions — Interview with Tom Jones, M.D.


VIDEO: Advances in Congenital Heart Therapy Technologies — Interview with Tom Jones, M.D.

VIDEO: Use of Virtual Reality to Aid Congenital Heart Disease — Interview with David M. Axelrod, M.D.

Medtronic Shares Two-Year Harmony Transcatheter Pulmonary Valve Results

Find more congenital heart disease (CHD) content


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