Transesophageal echocardiography (TEE) is quickly establishing itself as an essential tool in the interventional cardiologist’s daily toolbox. An alternative to the more traditional transthoracic echo, TEE provides higher quality images due to the esophagus’ location directly behind the heart. With the introduction of 3-D/4-D TEE, the technology has become a primary imaging modality to guide new, complex transcatheter structural heart procedures, including transcatheter aortic valve repair (TAVR), MitraClip, transcatheter mitral valve replacements (TMVR), left atrial appendage (LAA) occlusions, and septal defect closures.