Antiplatelet and Anticoagulation Therapies

This channel includes news and new technology innovations for cardiovascular pharmaceutics. This includes antiplatelet agents, anticoagulation drugs, international normalized ratio (INR) testing, oral anticoagulants, IV administered drugs such as Heprin, and dual antiplatelet therapy (DAPT). The most commonly used anticoagulant is warfarin, which available in generic form at a low cost. However, it has a narrow therapeutic window and its effectiveness is altered by food containing vitamin K. To regulate warfarin, regular INR testing is needed. The newer anticoagulation drugs are referred to as novel oral anticoagulant (NOAC). However, since some of these drugs are now more than six years old, they are commonly referred to as non-vitamin K oral anticoagulant (NOAC), and the newest term, direct oral anticoagulant (DOAC). NOAC or DOAC agents have much larger therapeutic windows, do not require INR testing. Aspirin and clopidogrel (Plavix) are the most commonly used antiplatelet agents for the prevention of heart attacks and stroke. They are often prescribed together as DAPT.

The Medicines Company, bivalirudin, Angiomax, litigation, Hospira Inc.
News | Cath Lab | July 22, 2015
July 22, 2015 — The Medicines Company announced the U.S. Court of Appeals for the Federal Circuit Court has ruled...
Xarelto, anticoagulant protocol, discharge, outcomes, DVT, PE
News | Antiplatelet and Anticoagulation Therapies | July 21, 2015
July 21, 2015 "” Two companion papers published in Academic Emergency Medicine  address the question of when it is...
platelet-like particles, PLPs, clotting, substitute, Carver, Lyon, NIBIB

Cartoon representation of a deformable platelet-like particle with fibrin nanobodies attached

Feature | Antiplatelet and Anticoagulation Therapies | July 13, 2015
July 13, 2015 - Researchers have created tiny gel particles that can perform the same essential functions as platelets...
idarucizumab, dabigatran, anticoagulant, Boehringer Ingelheim, RE-VERSE AD
News | Antiplatelet and Anticoagulation Therapies | July 07, 2015
July 7, 2015 - Results from an interim analysis of the Phase III RE-VERSE AD patient study demonstrate that 5 g of...
cangrelor, Kangreal, FDA approval, The Medicines Company, antiplatelet agent
Technology | June 22, 2015
June 22, 2015 - The Medicines Company announced the approval of cangrelor (Kengreal) by the U.S. Food and Drug...
VHA, dabigatran, patient adherence, JAMA, Mintu Turakhia
News | Antiplatelet and Anticoagulation Therapies | June 18, 2015
June 18, 2015 - Atrial fibrillation patients on the anticoagulant dabigatran were more likely to adhere to the...
News | Antiplatelet and Anticoagulation Therapies | June 11, 2015
June 11, 2015 - Patients who received a bare metal coronary stent did not display significant differences in rates of...
Brilinta, Ticagrelor, PEGASUS TIMI-54, ACC, results
Feature | Antiplatelet and Anticoagulation Therapies | June 10, 2015
June 9, 2015 - AstraZeneca announced full results from the PEGASUS-TIMI 54 study, a large-scale outcomes trial...
rivaroxaban, Xarelto, VENTURE-AF, VKA, atrial fibrillation, Heart Rhythm 2015
News | May 21, 2015
May 21, 2015 — Janssen Pharmaceuticals Inc. and its development partner Bayer HealthCare announced results from the...
antiplatelet medication, prasugrel, clopidogrel, risk algorithm, SCAI
Feature | Antiplatelet and Anticoagulation Therapies | May 18, 2015
May 18, 2015 — A risk assessment algorithm combining clinical risk factors and platelet function test results may help...
cilostazol, DAPT, bridge therapy, surgery, bleeding risk, SCAI
News | May 18, 2015
May 18, 2015 — Patients with a high-risk paclitaxel drug-eluting stent given the shorter-acting antiplatelet drug...
PROMETHEUS, prasugrel, clopidogrel, heart disease, bleeding, SCAI
Feature | May 15, 2015
May 15, 2015 — Prasugrel (Effient) is more likely to be given to lower-risk heart disease patients undergoing...
News | May 14, 2015
May 14, 2015 — A new study reports that antiplatelet drug ticagrelor (Brilinta) works faster and is more effective in...
heart stent, OAP therapy, ACS, patients, PCNA, SCAI, medication, prescribed
Feature | May 06, 2015
May 6, 2015 — People with acute coronary syndrome (ACS) who undergo an angioplasty procedure and receive a heart stent...
News | May 01, 2015
One life-threatening complication of lung cancer surgery is the formation of blood clots in the lungs (also called...