Off-label use of the St. Jude Amplatzer vascular plug devices offers a new solution for the minimally invasive repair of paravalvular leaks. Paravalvular leaks around surgical valve implants can result in poor outcomes, and the heart needing to work harder to pump can lead to heart failure. The small holes that cause paravalvular leak also form a Venturi effect, causing fast-moving jets that can lead to red blood cell destruction (hemolysis), causing anemia and fatigue.
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